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Preheat oven to 375°F (190°C).
In a large bowl, combine ground beef, onion, breadcrumbs, milk, egg, Worcestershire sauce, garlic powder, salt, and pepper.
Mix gently until just combined. Avoid overmixing.
Shape mixture into a loaf and place it on a foil-lined baking tray or in a loaf pan.
In a small bowl, mix ketchup, brown sugar, and mustard. Spread evenly over the top of the meatloaf.
ake for 55–60 minutes or until the internal temperature reaches 160°F (71°C).
Let rest for 10 minutes before slicing and serving.